A Regio- and Diastereoselective Platinum-Catalyzed Tandem [2+1]/[3+2] Cycloaddition Sequence

A regio- and diastereoselective platinum-catalyzed tandem [2+1]/[3+2] cycloaddition sequence.

Palladium-Catalyzed Oxidative Regio- and Diastereoselective Diarylating Carbocyclization of Dienynes

Transmetallation: A highly regio- and diastereoselective carbocyclization involving a palladium-catalyzed 1,2-addition of two carbon atoms across a conjugated diene has been developed (see scheme). The reaction is performed with dienynes and an oxygen tether containing a terminal or internal triple bond.

Regio- and diastereoselective reductive coupling of vinylepoxides catalyzed by titanocene chloride.

[reaction: see text] The Ti(III)-catalyzed reaction of a series of vinylepoxides leads, with regio- and E-diastereoselectivity control, to good-to-excellent yields of the corresponding homocoupling products. This homocoupling reaction, which involves a new C-C bond-forming method, takes place via a S(N)2' process between an allyltitanium species and the starting vinylepoxide. The process can be...

Regio- and diastereoselective nickel-catalyzed allylation of aromatic aldehydes with α-halo-β,β-difluoropropene derivatives.

A one-pot nickel-catalyzed allylation of aromatic aldehydes with α-halo-β,β-difluoropropene-containing compounds promoted by ZnEt(2) under mild conditions was described. The reaction displays moderate to good regio- and diastereoselectivity, tolerates a wide range of functional groups, and provides an efficient method for the synthesis of γ-fluorinated homoallylic alcohols.

Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines.

A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions.